The up-regulation profiles of p21 and RUNX1/AML1 correlate with myometrial infiltration in endometrioid endometrial carcinoma
نویسندگان
چکیده
Unitat de Recerca Biomèdica, Institut de Recerca de l’Hospital Universitari de la Vall d’Hebron, 08035 Barcelona, Spain Servei de Ginecologia, Hospital Universitari de la Vall d’Hebron, 08035 Barcelona, Spain Servei d’Anatomia Patològica, Hospital del Mar, 08003 Barcelona, Spain Servei d’Anatomia Patològica, Hospital Universitari de la Vall d’Hebron, 08035 Barcelona, Spain Facultat de Medicina, Universitat Autonoma de Barcelona, 08035 Barcelona, Spain
منابع مشابه
Tumor-infiltration of T-lymphocytes is inversely correlated with clinicopathologic factors in endometrial adenocarcinoma
OBJECTIVE The aim of this study was to determine the distribution of T-lymphocytes and their relationship with clinicopathologic factors in endometrial carcinoma. METHODS Samples were collected from 89 patients with endometrial endometrioid adenocarcinoma treated in Pusan National University Hospital from 2004 to 2011. Normal endometrial tissues were obtained from 30 hysterectomized women wit...
متن کاملTransvaginal/transrectal ultrasound for assessing myometrial invasion in endometrial cancer: a comparison of six different approaches
OBJECTIVE To compare the diagnostic performance of six different approaches for assessing myometrial infiltration using ultrasound in women with carcinoma of the corpus uteri. METHODS Myometrial infiltration was assessed by two-dimensional (2D) transvaginal or transrectal ultrasound in 169 consecutive women with well (G1) or moderately (G2) differentiated endometrioid type endometrial carcino...
متن کاملبررسی بروز PTEN بهروش ایمنوهیستوشیمی در آندومتر پرولیفراتیو نرمال، هیپرپلاستیک و کارسینوم آندومتریوئید
Background: Endometrial carcinoma is the most common malignancy of the female genital tract. Different molecular alterations have been described in endometrioid endometrial carcinoma that, the most frequently altered gene is mutations of PTEN. Up to 50-83% of endometrioid carcinoma reveal altered PTEN characterized by loss of expression. In endometrial hyperplasia, which are precursors of endom...
متن کامل[Prognostic parameters in FIGO stage I endometrial carcinoma of endometrioid type].
BACKGROUND/AIM Endometrial carcinoma is the most common malignant neoplasm of the female genital tract in developed countries. Endometrioid carcinoma represents about three-fourths of all endometrial carcinoma. The aim of this study was to examine pathologic parameters, age, and the 5-year survival of the patients with FIGO stage I endometrial carcinoma of endometrioid type and to assess the pr...
متن کاملERM/ETV5 up-regulation plays a role during myometrial infiltration through matrix metalloproteinase-2 activation in endometrial cancer.
We have described recently the Ets family transcription factor, ERM/ETV5, specifically up-regulated in endometrioid endometrial carcinoma (EEC) and associated with myometrial infiltration. Ets family members have been correlated to tumor progression by up-regulating the expression of matrix-degrading proteases. In the present study, we investigated the possibility that in EEC, ERM/ETV5 may act ...
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